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Roswell Park Comprehensive Cancer Center

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Coordinates: 42°53′50″N 78°52′01″W / 42.897185°N 78.866852°W / 42.897185; -78.866852
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"RPCI" redirects here. For the Presbyterian denomination, see Reformed Presbyterian Church of Ireland.
Roswell Park Comprehensive Cancer Center
National Comprehensive Cancer Network
Map
Geography
LocationBuffalo, New York, United States
Coordinates42°53′50″N 78°52′01″W / 42.897185°N 78.866852°W / 42.897185; -78.866852
Organization
Care systemMedicare
TypeSpecialist
Affiliated universityUniversity at Buffalo, the State University of New York
Services
StandardsNCI-designated Cancer Center
Beds133 (licensed)
SpecialityOncology, Teaching hospital
History
Former name(s)The Pathological Laboratory of the University of Buffalo (1898 - 1899)
The Gratwick Research Laboratory (1900 - 1911)
The State Institute for the Study of Malignant Disease (1912-1945)
Roswell Park Memorial Institute (1946 - 1991)
Roswell Park Cancer Institute (1992 - 2017)
Opened1898; 126 years ago (1898)
Links
Websitewww.roswellpark.org
ListsHospitals in New York State
Other linksList of NYS Public Benefit Corporations

Roswell Park Comprehensive Cancer Center is a cancer research and treatment center located in Buffalo, New York. Founded by surgeon Roswell Park in 1898, the center was the first in the United States to specifically focus on cancer research.[1][2][3] The center is usually called Roswell Park in short. The center, which conducts clinical research on cancer as well as the development new drugs, provides advanced treatment for all forms of adult and pediatric cancer, and serves as a member of the National Comprehensive Cancer Network. Roswell Park Comprehensive Cancer Center is as of 2019, the only upstate New York facility to hold the National Cancer Institute designation of "comprehensive cancer center".[4]

The Roswell Park campus, spread out in 15 separate buildings of approximately two million square feet, occupies 28 acres (11 ha) on the 100-acre (40 ha) Buffalo Niagara Medical Campus (BNMC) in downtown Buffalo, and includes 1,500,000 square feet (140,000 m2) of space equally distributed between clinical programs and research/education functions. A separate hospital building, completed in 1998, houses a diagnostic and treatment center. The campus also includes a medical research complex as well as research and education focused spaces.

History

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In 1898, the program that would later become the cancer center was established by Roswell Park, who was a professor of surgery at the University of Buffalo School of Medicine.[5] Park said that "Only through a deliberate well-planned, combined attack from various directions by means fitted for such work could real advances be made and further the relationship of laboratory work, clinical study and education must be closely associated."[5]

Research started in three rooms in the University of Buffalo School of Medicine but not long thereafter, it outgrew the rooms. Seeing the importance of dedicated cancer research, select Buffalo citizens donated funds to purchase land and construct a new building. The largest contributor was Mrs. William Gratwick (wife of William H. Gratwick, the founder of Gratwick, Smith & Fryer Lumber Co.), who donated $25,000. The Gratwick Research Laboratory of the University of Buffalo was constructed in 1901 and was located at High and Elm streets.[6]

Park wrote books, gave lectures, and was the administrator at the cancer research center. In 1904, Park stepped down and Harvey R. Gaylord took over as the center's second director. Park remained as the chairman of the board of trustees.[7]

In coming decades the center was renamed the Roswell Park Cancer Institute, a name it retained for decades until 2018, when its current name was implemented. The Roswell Park Cancer Institute was usually called Roswell Park or RPCI for short.

Notable facts

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  • Founded in 1898 as the world's first institute devoted exclusively to cancer research[8] 1884 – On May 31, Memorial Sloan Kettering Cancer Center is founded as New York Cancer Hospital at 106th Street and Central Park West in Manhattan. New York Cancer Hospital is the first institution in the United States devoted exclusively to the treatment and research of cancer.
  • Gerty Cori was the first woman to receive the Nobel Prize in Physiology or Medicine.[9]
  • The center's first female leader, Candace S. Johnson was named President & CEO in February 2015.[10]
  • Leads New York State in the number of robotic cystectomies performed[11]
  • Established one of the nation's first long-term survivors clinics for childhood cancer patients[12]

Discoveries and advancements in cancer care

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Discovery of how the human body converts glucose to glycogen

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Gerty Cori and Carl Cori jointly won the 1947 Nobel Prize in Physiology or Medicine for their discovery of the way in which the body converts glucose to glycogen.

Drs. Gerty and Carl Cori jointly won the 1947 Nobel Prize in Physiology or Medicine, "for their discovery of the course of the catalytic conversion of glycogen."[13] Their research leading to the discovery began during their tenure at Roswell Park (then called the New York State Institute for the Study of Malignant Diseases), from 1922 to 1931.[14]

Alternative breast cancer treatments

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Thomas Dao (1921–2009), served as director of the breast surgery department from 1957 to 1988, where he developed breast cancer treatment alternatives.[15]

Development of photodynamic therapy

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In 1975, Thomas Dougherty successfully treated preclinical models of cancer using photodynamic therapy (PDT) techniques for the first time.[16][17] In 1978, he conducted the first PDT clinical trial.[18][19] Today, PDT is an FDA-approved method for treating specific kinds of cancer, and is used around the world.

Discovery of PSA

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Research resulting in the discovery of the prostate-specific antigen (PSA) was led by T. Ming Chu in the 1970s.[20] His team subsequently developed a way to detect the PSA protein in blood as a simple diagnostic test.[21] Since its FDA approvals in 1986 and 1994, an estimated one billion PSA tests have been given.

Research on 5-fluorouracil + leucovorin

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Biochemist Marie Hakala, PhD[22][23] first observed that 5-fluorouracil becomes more effective in treating cancer cells when calcium leucovorin is added.[24][25] This discovery paved the way for the development of 5-FU + leucovorin therapy, which was for many years the gold standard of chemotherapy for colorectal cancer.

Research on SurVaxM

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SurVaxM, a cancer immunotherapy vaccine, was awarded orphan drug status by the United States Food and Drug Administration in 2017. A phase II clinical trial of SurVaxM has shown that the vaccine, when combined with standard therapy, is more effective than standard therapies alone.[26]

Organization

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Education

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Roswell Park offers both Master's and PhD programs in Cancer Sciences.[27] These programs are offered in collaboration with the University at Buffalo Jacobs School of Medicine.[28]

Reputation

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Roswell Park Comprehensive Cancer Center has received numerous accolades for the quality of healthcare provided.

Accreditation

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Patient care

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Scott Bieler Clinical Sciences Center

Roswell Park provides comprehensive care for a wide range of cancers.[46]

Specialized treatments

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Roswell Park offers specialized treatments, services and therapies to treat cancer, as well as services to support patients undergoing cancer treatment.[47][48]

Collaborations

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CIMAvax

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Roswell Park was the first American institution to receive FDA permission to conduct clinical trials of CIMAvax, a Cuban medical therapy developed by Centro de Immunologica Molecular, La Habana, Cuba.[49][50]

Ovarian Cancer SPORE

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The Ovarian Cancer SPORE is a collaboration between Roswell Park and University of Pittsburgh Cancer Institute (UPCI). The SPORE project includes multiple research projects, core supportive structures, and career development programs.[51]

Cancer Registries

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Stacey Scott Lung Cancer Registry

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Together with the British Columbia Cancer Agency, Vancouver, Canada and Vrije Universiteit, Amsterdam, the Netherlands, Roswell Park manages the Stacey Scott Lung Cancer Registry.[52]

Familial Ovarian Cancer Registry

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Founded in 1990 by Steven Piver, the Familial Ovarian Cancer Registry houses information relating to family history and lifestyle of patients and families with histories of ovarian cancer.[53][54]

Research and training collaborations

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Roswell Park collaborates with institutions around the world to strengthen cancer training and research programs.[55]

See also

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References

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  1. ^ Rusch, Harold P (1985). "Beginnings of Cancer Research Centers in the United States". Journal of the National Cancer Institute. 74 (2): 391–403. doi:10.1093/jnci/74.2.391. PMID 3883036. The first center in the United States devoted specifically for research on cancer was founded by Dr. Roswell Park in 1898. Dr. Park, a professor of surgery at the University of Buffalo (Buffalo, NY), with Mr. Edward Butler, publisher of the Buffalo Evening News, in 1897 persuaded the legislators of New York State to appropriate $7,500 for cancer research.
  2. ^ "Roswell Park celebrates 120 years with time capsule". WGRZ. April 25, 2018. Retrieved May 10, 2021.
  3. ^ "1898-1950". Roswell Park Comprehensive Cancer Center. Retrieved May 10, 2021.
  4. ^ "Roswell Park Comprehensive Cancer Center". National Cancer Institute. 2019. Retrieved May 11, 2021.
  5. ^ a b Mirand, Edwin A (1998). Legacy And History Of Roswell Park Cancer Institute, 1898-1998. Virginia Beach, VA: The Donning Company. p. 9. ISBN 9781578642816.
  6. ^ Mirand, Edwin A (1998). Legacy And History Of Roswell Park Cancer Institute, 1898-1998. Virginia Beach, VA: The Donning Company. p. 16. ISBN 9781578642816.
  7. ^ Mirand, Edwin A (1998). Legacy And History Of Roswell Park Cancer Institute, 1898-1998. Virginia Beach, VA: The Donning Company. p. 21. ISBN 9781578642816.
  8. ^ "1898-1950". Roswell Park Comprehensive Cancer Center. Retrieved 2021-05-10.
  9. ^ "Nobel Prize awarded women". The Nobel Prize. Nobel Prize Outreach AB. Retrieved May 12, 2021.
  10. ^ "Roswell Park Announces Candace S. Johnson, PhD, as Institute's 15th President & CEO". Roswell Park Comprehensive Cancer Center. Retrieved 2021-05-10.
  11. ^ "Bladder Cancer Surgery". Roswell Park Comprehensive Cancer Center. Retrieved May 13, 2021.
  12. ^ "Roswell Park Creates Center of Excellence for Adolescents and Young Adults with Cancer". Roswell Park Comprehensive Cancer Center. February 11, 2011. Retrieved May 13, 2021.
  13. ^ "The Nobel Prize in Physiology or Medicine 1947". The Nobel Prize. Nobel Prize Outreach AB. Retrieved May 12, 2021.
  14. ^ "Gerty Cori - Biographical". The Nobel Prize. Nobel Prize Outreach AB. Retrieved May 10, 2021.
  15. ^ Hevesi, Dennis (July 25, 2009). "Dr. Thomas Dao, Expert on Treatment of Breast Cancer, Dies at 88". Health. The New York Times. Retrieved July 26, 2009.
  16. ^ Dougherty, Thomas; Grindey, G; Fiel, R; Weishaupt, K; Boyle, D (1955). "Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light". Journal of the National Cancer Institute. 55 (1): 115–121. doi:10.1093/jnci/55.1.115. PMID 1159805.
  17. ^ "Remembering Dr. Dougherty, Chief Emeritus, PDT Center". American Society for Photobiology. Retrieved May 11, 2021.
  18. ^ Dougherty, Thomas; Kaufman, Jerome; Goldfarb, Abraham; Weishaupt, Kenneth; Boyle, Donn; Mittleman, Arnold (1987). "Photoradiation Therapy for the Treatment of Malignant Tumors" (PDF). Cancer Research. 38 (8): 2628–2635. PMID 667856 – via PubMed.
  19. ^ "1970s & 1980s". Roswell Park Comprehensive Cancer Center. Retrieved May 11, 2021.
  20. ^ "From the History Books: Blood Test Gives Urologists a New Way to Detect Prostate Cancer". The William P. Didusch Center for Urologic History. American Urological Association. Retrieved May 11, 2021. In 1979, Chu's colleagues, led by M.C. Wang, characterized and purified the antigen, and in 1980, Lawrence D. Papsidero and fellow scientists confirmed its presence in the blood of prostate cancer patients. Amidst that activity, Chu introduced the PSA test, a screen that picks up early prostate cancer by detecting elevated levels of PSA in the blood.
  21. ^ Roswell Park Comprehensive Cancer Center (March 30, 2021). "T. Ming Chu: The Man Behind the PSA Test". Cancer History Project. Retrieved May 11, 2021.
  22. ^ "Marie T. Hakala-Zakrzewski". The Buffalo News. Legacy.com. Retrieved May 12, 2021.
  23. ^ "In Memoriam: Marie Hakala-Zakrzewski". American Association for Cancer Research. Retrieved May 12, 2021.
  24. ^ Evans, Mark; Laskin, Jeffrey; Hakala, Marie (September 1981). "Effects of Excess Folates and Deoxyinosine on the Activity and Site of Action of 5-Fluorouracil". Cancer Research. 41 (9): 3288–3295. PMID 6973389 – via PubMed.
  25. ^ Berger, S; Hakala, Marie (May 1990). "Calcium leucovorin and 5-fluorouridine cytotoxicity". Journal of the South Carolina Medical Association. 86 (5): 284–289. PMID 2242115 – via PubMed.
  26. ^ "SurVaxM with standard therapy in newly diagnosed glioblastoma: Phase II trial update". ASCO. Retrieved January 23, 2024.
  27. ^ "Master's & PhD Degrees in Cancer Sciences". Roswell Park Comprehensive Cancer Center. Retrieved January 23, 2024.
  28. ^ "Cancer Sciences PhD, Roswell Park Graduate Division". University at Buffalo. Retrieved January 23, 2024.
  29. ^ "Roswell Park Ranks 14th on List of Nation's Best Hospitals for Cancer". Roswell Park Comprehensive Cancer Center. 30 July 2019. Retrieved June 22, 2020.
  30. ^ "Roswell Park says ranking on national list meaningful to doctors, patients". The Buffalo News. July 30, 2019. Retrieved June 22, 2020.
  31. ^ "Roswell Park Comprehensive Cancer Center". U.S. News & World Report. Retrieved May 10, 2021.
  32. ^ "Roswell Park Comprehensive Cancer Center Colon Cancer Surgery Scorecard". U.S. News & World Report. Retrieved May 11, 2021.
  33. ^ "Roswell Park Comprehensive Cancer Center Lung Cancer Surgery Scorecard". U.S News & World Report. Retrieved May 11, 2021.
  34. ^ "Blue Distinction Centers for Cancer Care - Directory of Providers" (PDF). BlueCross BlueShield (PDF). Blue Cross Blue Shield Association. January 27, 2021. p. 15. Retrieved May 11, 2021.
  35. ^ "Blue Distinction Centers for Transplants - Directory of Providers" (PDF). BlueCross BlueShield (PDF). Blue Cross Blue Shield Association. April 14, 2021. p. 17. Retrieved May 11, 2021.
  36. ^ "Blue Distinction Centers for Cellular Immunotherapy - Directory of Providers" (PDF). BlueCross BlueShield (PDF). Blue Cross Blue Shield Association. March 31, 2021. p. 3. Retrieved May 11, 2021.
  37. ^ "Health Systems Recognized by IHI". Institute for Healthcare Improvement. 2021. Retrieved May 11, 2021.
  38. ^ "Accredited Facility Search". American College of Radiology (XLS). Retrieved May 12, 2021.
  39. ^ "Cancer Centers of Excellence Network". Optum. 2021. Retrieved May 12, 2021.
  40. ^ "Screening Centers". GO2 Foundation For Lung Cancer. Retrieved May 12, 2021.
  41. ^ "QOPI Certified Practices". American Society of Clinical Oncology and Association for Clinical Oncology. Retrieved May 12, 2021.
  42. ^ "Roswell Park Comprehensive Cancer Center". American College of Surgeons. Retrieved 2021-05-10.
  43. ^ "Roswell Park Comprehensive Cancer Center". National Cancer Institute. Retrieved 2021-05-10.
  44. ^ "Roswell Park Comprehensive Cancer Center". National Comprehensive Cancer Network. Retrieved 2021-05-10.
  45. ^ "Be The Match - Roswell Park Comprehensive Cancer Center". Be The Match. National Marrow Donor Program. Retrieved 2021-05-10.
  46. ^ "Cancer Types". Roswell Park Comprehensive Cancer Center. Retrieved May 11, 2021.
  47. ^ "Treatments at Roswell Park". Roswell Park Comprehensive Cancer Center. Retrieved May 11, 2021.
  48. ^ "Support". Roswell Park Comprehensive Cancer Center. Retrieved May 11, 2021.
  49. ^ "Gov. Cuomo Announces Landmark Roswell Park Study Bringing Cuban Lung Cancer Vaccine to U.S. Patients, and Approval of Historic U.S. Government License Authorizing U.S.–Cuba Commercial Partnership to Fast-Track Biotech Development". Roswell Park Comprehensive Cancer Center. October 26, 2016. Retrieved May 10, 2021.
  50. ^ Kroll, David (November 26, 2016). "Fidel Castro-Supported Lung Cancer Vaccine To Be Tested In U.S. Clinical Trials". Forbes. Retrieved May 10, 2021.
  51. ^ "Roswell Park - UPCI Ovarian Cancer SPORE Overview". Roswell Park Comprehensive Cancer Center. Retrieved May 13, 2021.
  52. ^ "Stacey Scott Lung Cancer Registry". Roswell Park Comprehensive Cancer Center. Retrieved May 12, 2021.
  53. ^ "About The Familial Ovarian Cancer Registry". Roswell Park Comprehensive Cancer Center. Retrieved May 13, 2021.
  54. ^ "What is the Registry?". Roswell Park Comprehensive Cancer Center. Retrieved May 13, 2021.
  55. ^ "International Collaborations". Roswell Park Comprehensive Cancer Center. Retrieved May 12, 2021.
  56. ^ "International Team of Researchers Reports Promising Results in Study of Pediatric Neuroblastoma". Roswell Park Comprehensive Cancer Center. November 6, 2015. Retrieved May 13, 2021.
  57. ^ "Roswell Park Establishes Partnership with Jagiellonian University in Krakow, Poland". Roswell Park Comprehensive Cancer Center. November 15, 2018. Retrieved May 13, 2021.
  58. ^ "Roswell Park Comprehensive Cancer Center to Train Clinical Staff from Saudi Hospital in Cancer Care". Roswell Park Comprehensive Cancer Center. November 17, 2010. Retrieved May 12, 2021.
  59. ^ "Intercontinental Oncology Partnership Brings Access to Specialized Cancer Care to Nigeria". Roswell Park Comprehensive Cancer Center. June 30, 2015. Retrieved May 12, 2021.
  60. ^ "On Solidarity Trip to Israel, Governor Cuomo Announces Establishment of Joint Program Uniting U.S. and Israeli Cancer Experts in Effort to Research and Develop New Cancer Therapies and Precision Diagnostic Tools". Roswell Park Comprehensive Cancer Center. July 2, 2019. Retrieved May 13, 2021.
  61. ^ "Roswell Park Designated Scientific Lead for Ongoing Population Assessment of Tobacco and Health (PATH) Study". Roswell Park Comprehensive Cancer Center. April 4, 2021. Retrieved May 13, 2021.
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